Modelling mutations for cancer cure

By | Bioscience and medicine | No Comments
The p53 tumour suppressor protein, when it works properly, helps to prevent cancer. It does so by inducing the arrest of the cell cycle, by repairing DNA, and by causing apoptosis – a process of programmed cell death. However, p53 also regularly mutates, and either loses the ability to bind DNA, or is destabilised and unfolds, which induces the growth of DNA-damaged cells. Half of all cancers are due to this mutation – so Zohra Ouaray, a PhD Research Student in the School of Chemistry at the University of Southampton, is using Emerald to model what happens and look at...
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Designing better drugs, faster

By | Bioscience and medicine | No Comments
Chris Skylaris, Reader in Computational Chemistry at the University of Southampton, develops quantum mechanical calculations for chemistry simulation and drug discovery. He has developed a quantum mechanical method that dramatically cuts the computing time needed for large-scale calculations – expanding research possibilities, and attracting interest from drugs companies who are looking for more accurate molecular simulation tools for their research. The theory of quantum mechanics is necessary if you want to do any simulation of microscopic particles, he says. “You can’t do it with classical mechanics – if you want to describe how atoms and electrons move, they don’t follow...
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Modelling downward sailing conditions

By | Innovation and infrastructure | No Comments
North Sails are one of the largest sail making companies, with a particular emphasis upon and commitment to technical development. This ranges from the materials used to the manufacturing process and the design of the sail. North Sails operate world-wide, producing sails for boats ranging from 4m dinghies to 200m super yachts, from classic cruising yachts to the Americas Cup racing catamarans. Designing the shape of sails is a challenging task and traditionally completed using experience and trial and error. The fundamental design issue is one of matching the structural properties of the sail to the fluid dynamic loading from the...
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World leaders in Performance Sports Engineering

By | Advanced materials, News | No Comments
The Wolfson Unit at the University of Southampton have been working with America’s Cup teams for over 30 years, using experimental testing in towing tanks and wind tunnels to define and improve the performance of the racing yachts. The America’s Cup, the world’s oldest international sporting trophy, was sailed in mono-hulls with traditional soft sails until 2010 but for the 2013 Americas Cup the yachts have been changed to catamarans with solid wing sails. The result is a four-fold increase in speed, and a shift in performance prediction requirements from straight line speed through the water to dynamic manoeuvres and...
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